Serial section electron microscopy (ssEM), a technique where volumes of tissue can be anatomically reconstructed by imaging consecutive tissue slices, has proven to be a powerful tool for the investigation of brain anatomy. Between the process of cutting the slices—or “sections”—and imaging them, however, handling 100-106 delicate sections remains a bottleneck in ssEM, especially for batches in the “mesoscale” regime, i.e.,102-103 sections. Our lab is developing a tissue section handling device that transports and positions sections accurately and repeatably for automated, robotic section pick-up and placement onto an imaging substrate.
https://precisionbiosystemslab.org/wp-content/uploads/2019/06/neuroanatomical-imaging-FI.png 300 300 Academic Web Pages https://precisionbiosystemslab.org/wp-content/uploads/2018/09/clear.png Academic Web Pages2019-06-23 12:59:342019-10-10 17:53:56Neuroanatomical Imaging
https://precisionbiosystemslab.org/wp-content/uploads/2019/08/Congrats-Dr.-Timothy-Lee-300.jpg 300 300 Academic Web Pages https://precisionbiosystemslab.org/wp-content/uploads/2018/09/clear.png Academic Web Pages2019-06-13 17:05:502019-10-25 14:03:26Congrats Dr. Timothy Lee
Dr. Timothy Lee successfully defended his thesis this summer. His thesis focused on automating the collection of serial nano-sections sections used to image and analyze up to 1 cubic milimieter of tissue!